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1

Motor and Nonmotor Symptoms of Parkinson’s Disease: Antagonistic Pleiotropy Phenomena Derived from α -Synuclein Evolvability?

Takamatsu, Yoshiki, Fujita, Masayo, Ho, Gilbert J., Wada, Ryoko, Sugama, Shuei, Takenouchi, Takato, Waragai, Masaaki, Masliah, Eliezer, Hashimoto, Makoto

Journal:

Parkinson's Disease

Year:

2018

Language:

english

File:

PDF, 1.61 MB

english, 2018

2

P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases

Takato Takenouchi, Kazunari Sekiyama, Akio Sekigawa, Masayo Fujita, Masaaki Waragai, Shuei Sugama, Yoshifumi Iwamaru, Hiroshi Kitani, Makoto Hashimoto

Journal:

Archivum Immunologiae et Therapiae Experimentalis

Year:

2010

Language:

english

File:

PDF, 232 KB

english, 2010

3

Anti-Prion Activity of Brilliant Blue G

Iwamaru, Yoshifumi, Takenouchi, Takato, Murayama, Yuichi, Okada, Hiroyuki, Imamura, Morikazu, Shimizu, Yoshihisa, Hashimoto, Makoto, Mohri, Shirou, Yokoyama, Takashi, Kitani, Hiroshi, Lasmezas, Corinn

Journal:

Year:

2012

Language:

english

File:

PDF, 1.87 MB

english, 2012

4

Co-treatment with dexamethasone and octanoate induces adipogenesis in 3T3-L1 cells

Takato Takenouchi, Yoshiharu Takayama, Toshiaki Takezawa

Journal:

Cell Biology International

Year:

2004

Language:

english

File:

PDF, 730 KB

english, 2004

5

Role of caveolin-1 and cytoskeletal proteins, actin and vimentin, in adipogenesis of bovine intramuscular preadipocyte cells

Takato Takenouchi, Norikazu Miyashita, Kyohei Ozutsumi, Michael T. Rose, Hisashi Aso

Journal:

Cell Biology International

Year:

2004

Language:

english

File:

PDF, 444 KB

english, 2004

6

Establishment and characterization of SV40 large T antigen-immortalized cell lines derived from fetal bovine brain tissues after prolonged cryopreservation

Takato Takenouchi, Yoshifumi Iwamaru, Mitsuru Sato, Takashi Yokoyama, Morikazu Shinagawa, Hiroshi Kitani

Journal:

Cell Biology International

Year:

2007

Language:

english

File:

PDF, 1.50 MB

english, 2007

7

Establishment of an SV40 large T antigen-immortalized bovine brain cell line and its neuronal differentiation by dibutyryl-cyclic AMP

Takato Takenouchi, Yoshifumi Iwamaru, Mitsuru Sato, Takashi Yokoyama, Hiroshi Kitani

Journal:

Cell Biology International

Year:

2009

Language:

english

File:

PDF, 326 KB

english, 2009

8

α-Synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease

Makoto Hashimoto, Takato Takenouchi, Edward Rockenstein, Eliezer Masliah

Journal:

Journal of Neurochemistry

Year:

2003

Language:

english

File:

PDF, 455 KB

english, 2003

9

The chemical synthesis and binding affinity to the EGF receptor of the EGF-like domain of heparin-binding EGF-like growth factor (HB-EGF)

Song Yub Shin, Tetsuo Yokoyama, Takato Takenouchi, Eisuke Munekata

Journal:

Journal of Peptide Science

Year:

2003

Language:

english

File:

PDF, 125 KB

english, 2003

10

Lactoferrin induces cell surface retention of prion protein and inhibits prion accumulation

Yoshifumi Iwamaru, Yoshihisa Shimizu, Morikazu Imamura, Yuichi Murayama, Ryo Endo, Yuichi Tagawa, Yuko Ushiki-Kaku, Takato Takenouchi, Hiroshi Kitani, Shirou Mohri, Takashi Yokoyama, Hiroyuki Okada

Journal:

Journal of Neurochemistry

Year:

2008

Language:

english

File:

PDF, 599 KB

english, 2008

11

The activation of P2X7 receptor induces cathepsin D-dependent production of a 20-kDa form of IL-1β under acidic extracellular pH in LPS-primed microglial cells

Takato Takenouchi, Yoshifumi Iwamaru, Shuei Sugama, Mitsutoshi Tsukimoto, Masayo Fujita, Akio Sekigawa, Kazunari Sekiyama, Mitsuru Sato, Shuji Kojima, Bruno Conti, Makoto Hashimoto, Hiroshi Kitani

Journal:

Journal of Neurochemistry

Year:

2011

Language:

english

File:

PDF, 639 KB

english, 2011

12

Nuclear transfer using a bovine mammary epithelial cell line (BMEC)

Satoshi AKAGI, Seiya TAKAHASHI, Katsuhiro OHKOSHI, Takato TAKENOUCHI, Manabu SHIMIZU, Masaya GESHI, Noritaka ADACHI, Dai-ichiro FUCHIMOTO, Yoshiaki IZAIKE, Hisashi ASO

Journal:

Animal Science Journal

Year:

2002

Language:

english

File:

PDF, 73 KB

english, 2002

13

A novel isolation method for macrophage-like cells from mixed primary cultures of adult rat liver cells

Hiroshi Kitani, Takato Takenouchi, Mitsuru Sato, Miyako Yoshioka, Noriko Yamanaka

Journal:

Journal of Immunological Methods

Year:

2010

Language:

english

File:

PDF, 2.82 MB

english, 2010

14

Activin as an anti-inflammatory cytokine produced by microglia

Shuei Sugama, Takato Takenouchi, Hiroshi Kitani, Masayo Fujita, Makoto Hashimoto

Journal:

Journal of Neuroimmunology

Year:

2007

Language:

english

File:

PDF, 1.29 MB

english, 2007

15

Differential microglial activation between acute stress and lipopolysaccharide treatment

Shuei Sugama, Takato Takenouchi, Masayo Fujita, Bruno Conti, Makoto Hashimoto

Journal:

Journal of Neuroimmunology

Year:

2009

Language:

english

File:

PDF, 1.06 MB

english, 2009

16

Microglial activation is inhibited by corticosterone in dopaminergic neurodegeneration

Shuei Sugama, Takato Takenouchi, Hiroshi Kitani, Masayo Fujita, Makoto Hashimoto

Journal:

Journal of Neuroimmunology

Year:

2009

Language:

english

File:

PDF, 6.74 MB

english, 2009

17

Cold stress induced morphological microglial activation and increased IL-1β expression in astroglial cells in rat brain

Shuei Sugama, Takato Takenouchi, Masayo Fujita, Hiroshi Kitani, Makoto Hashimoto

Journal:

Journal of Neuroimmunology

Year:

2011

Language:

english

File:

PDF, 3.68 MB

english, 2011

18

Chemical synthesis and biological activity of the EGF-like domain of heparin-binding epidermal growth factor-like growth factor (HB-EGF)

SONG YUB SHIN, TAKATO TAKENOUCHI, TETSUO YOKOYAMA, TETSUYA OHTAKI, EISUKE MUNEKATA

Journal:

Chemical Biology & Drug Design

Year:

1994

Language:

english

File:

PDF, 482 KB

english, 1994

19

Chemical synthesis and biological activities of the EGF-like domain of mouse schwannoma-derived growth factor (SDGF)

TAKATO TAKENOUCHI, MISA KADOSAKA, SONG YUB SHIN, EISUKE MUNEKATA

Journal:

Chemical Biology & Drug Design

Year:

1995

Language:

english

File:

PDF, 495 KB

english, 1995

20

Reduced Neuritic Outgrowth and Cell Adhesion in Neuronal Cells Transfected with Human α-Synuclein

Takato Takenouchi, Makoto Hashimoto, Leigh J. Hsu, Bartek Mackowski, Edward Rockenstein, Margaret Mallory, Eliezer Masliah

Journal:

Molecular and Cellular Neuroscience

Year:

2001

Language:

english

File:

PDF, 885 KB

english, 2001

21

1H NMR study on the conformation of bacitracin A in aqueous solution

Naohiro Kobayashi, Takato Takenouchi, Satoshi Endo, Eisuke Munekata

Journal:

Year:

1992

Language:

english

File:

PDF, 356 KB

english, 1992

22

Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line

Takato Takenouchi, Kazumasa Ogihara, Mitsuru Sato, Hiroshi Kitani

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2005

Language:

english

File:

PDF, 320 KB

english, 2005

23

γ-Irradiation induces P2X7 receptor-dependent ATP release from B16 melanoma cells

Yasuhiro Ohshima, Mitsutoshi Tsukimoto, Takato Takenouchi, Hitoshi Harada, Akina Suzuki, Mitsuru Sato, Hiroshi Kitani, Shuji Kojima

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2010

Language:

english

File:

PDF, 539 KB

english, 2010

24

Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia

Mika Yanagitai, Sayaka Itoh, Tomomi Kitagawa, Takato Takenouchi, Hiroshi Kitani, Takumi Satoh

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 459 KB

english, 2012

25

Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages

Ayumi Kawano, Mitsutoshi Tsukimoto, Taisei Noguchi, Noriyuki Hotta, Hitoshi Harada, Takato Takenouchi, Hiroshi Kitani, Shuji Kojima

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 492 KB

english, 2012

26

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages

Ayumi Kawano, Mitsutoshi Tsukimoto, Daisuke Mori, Taisei Noguchi, Hitoshi Harada, Takato Takenouchi, Hiroshi Kitani, Shuji Kojima

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 344 KB

english, 2012

27

Single-chain variable fragment intrabody impairs LPS-induced inflammatory responses by interfering with the interaction between the WASP N-terminal domain and Btk in macrophages

Chisato Sakuma, Mitsuru Sato, Takato Takenouchi, Joe Chiba, Hiroshi Kitani

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 761 KB

english, 2012

28

Ibuprofen ameliorates protein aggregation and astrocytic gliosis, but not cognitive dysfunction, in a transgenic mouse expressing dementia with Lewy bodies-linked P123H β-synuclein

Kazunari Sekiyama, Masayo Fujita, Akio Sekigawa, Yoshiki Takamatsu, Masaaki Waragai, Takato Takenouchi, Shuei Sugama, Makoto Hashimoto

Journal:

Neuroscience Letters

Year:

2012

Language:

english

File:

PDF, 887 KB

english, 2012

29

Isolation and characterization of macrophages from a mixed primary culture of bovine liver cells

Hiroshi Kitani, Miyako Yoshioka, Takato Takenouchi, Mitsuru Sato, Noriko Yamanaka

Journal:

Veterinary Immunology and Immunopathology

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

30

α-Synuclein Promotes Mitochondrial Deficit and Oxidative Stress

Leigh J. Hsu, Yutaka Sagara, Armando Arroyo, Edward Rockenstein, Abbyann Sisk, Margaret Mallory, Jeff Wong, Takato Takenouchi, Makoto Hashimoto, Eliezer Masliah

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 1.73 MB

english, 2000

31

The Role of NAC in Amyloidogenesis in Alzheimer's Disease

Makoto Hashimoto, Takato Takenouchi, Margaret Mallory, Eliezer Masliah, Ayako Takeda, Janetta G. Culvenor, Catriona A. McLean, Bruce C.V. Campbell, Colin L. Masters, Qiao-Xin Li, Pekka Jakala, Tobias

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 57 KB

english, 2000

32

Amyloid β-Peptide-induced Inhibition of MTT Reduction in PC12h and C1300 Neuroblastoma Cells: Effect of Nitroprusside

Takato Takenouchi, Eisuke Munekata

Journal:

Year:

1998

Language:

english

File:

PDF, 229 KB

english, 1998

33

Structure, tissue distribution, and pharmacological characterization of Xenopus orexins

Megumi Shibahara, Takeshi Sakurai, Tadahiro Nambu, Takato Takenouchi, Hisashi Iwaasa, Shin-Ichiro Egashira, Masaki Ihara, Katsutoshi Goto

Journal:

Year:

1999

Language:

english

File:

PDF, 593 KB

english, 1999

34

Serotonin increases cytoplasmic Ca2+ concentration in PC12h cells: effect of tachykinin peptides

Takato Takenouchi, Eisuke Munekata

Journal:

Neuroscience Letters

Year:

1998

Language:

english

File:

PDF, 191 KB

english, 1998

35

Isolation and characterization of Cox17p from porcine heart by determining its survival-promoting activity in NIH3T3 cells

Takato Takenouchi, Masahiro Fujimoto, Akiko Shimamoto, Eisuke Munekata

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1999

Language:

english

File:

PDF, 491 KB

english, 1999

36

Protective Role of Endogenous Gangliosides for Lysosomal Pathology in a Cellular Model of Synucleinopathies

Jianshe Wei, Masayo Fujita, Masaaki Nakai, Masaaki Waragai, Akio Sekigawa, Shuei Sugama, Takato Takenouchi, Eliezer Masliah, Makoto Hashimoto

Journal:

The American Journal of Pathology

Year:

2009

Language:

english

File:

PDF, 1.47 MB

english, 2009

37

Trophic effects of substance P and β-amyloid peptide on dibutyryl cyclic amp-differentiated human leukemic (HL-60) cells

Takato Takenouchi, Eisuke Munekata

Journal:

Year:

1995

Language:

english

File:

PDF, 463 KB

english, 1995

38

Prion infection correlates with hypersensitivity of P2X7 nucleotide receptor in a mouse microglial cell line

Takato Takenouchi, Yoshifumi Iwamaru, Morikazu Imamura, Nobuko Kato, Shuei Sugama, Masayo Fujita, Makoto Hashimoto, Mitsuru Sato, Hiroyuki Okada, Takashi Yokoyama, Shirou Mohri, Hiroshi Kitani

Journal:

Year:

2007

Language:

english

File:

PDF, 689 KB

english, 2007

39

Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7

Fumie Hattori, Yasuhiro Ohshima, Shizuka Seki, Mitsutoshi Tsukimoto, Mitsuru Sato, Takato Takenouchi, Akina Suzuki, Erina Takai, Hiroshi Kitani, Hitoshi Harada, Shuji Kojima

Journal:

European Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 428 KB

english, 2012

40

Cytochalasin D enhances the accumulation of a protease-resistant form of prion protein in ScN2a cells: involvement of PI3 kinase/Akt signalling pathway

Takenouchi, Takato, Iwamaru, Yoshifumi, Imamura, Morikazu, Fukuhara, Shigetomo, Sugama, Shuei, Sato, Mitsuru, Mochizuki, Naoki, Hashimoto, Makoto, Yokoyama, Takashi, Mohri, Shirou, Kitani, Hiroshi

Journal:

Cell Biology International

Year:

2012

Language:

english

File:

PDF, 561 KB

english, 2012

41

Reversible conversion of epithelial and mesenchymal phenotypes in SV40 large T antigen-immortalized rat liver cell lines

Takenouchi, Takato, Yoshioka, Miyako, Yamanaka, Noriko, Kitani, Hiroshi

Journal:

Cell Biology International Reports

Year:

2010

Language:

english

File:

PDF, 718 KB

english, 2010

42

A sub-10-ns 16×16 multiplier using 0.6-μm CMOS technology

Oowaki, Y., Numata, K., Tsuchiya, K., Tsuda, K., Takato, H., Takenouchi, N., Nitayama, A., Kobayashi, T., Chiba, M., Watanabe, S., Ohuchi, K., Hojo, A.

Journal:

IEEE Journal of Solid-State Circuits

Year:

1987

Language:

english

File:

PDF, 1019 KB

english, 1987

43

Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle

Kojima, Shuji, Negishi, Yusuke, Tsukimoto, Mitsutoshi, Takenouchi, Takato, Kitani, Hiroshi, Takeda, Ken

Journal:

Year:

2014

Language:

english

File:

PDF, 977 KB

english, 2014

44

Characterization of the liver-macrophages isolated from a mixed primary culture of neonatal swine hepatocytes

Kitani, Hiroshi, Yoshioka, Miyako, Takenouchi, Takato, Sato, Mitsuru, Yamanaka, Noriko

Journal:

Results in Immunology

Year:

2014

Language:

english

File:

PDF, 3.09 MB

english, 2014

45

Corrigendum to “Single-chain variable fragment intrabody impairs LPS-induced inflammatory responses by interfering with the interaction between the WASP N-terminal domain and Btk in macrophages” [Biochem. Biophys. Res. Commun. 423 (2012) 164–169]

Sakuma, Chisato, Sato, Mitsuru, Takenouchi, Takato, Chiba, Joe, Kitani, Hiroshi

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 516 KB

english, 2013

46

Inhibitory effects of β-amyloid peptides on nicotine-induced Ca2+ influx in PC12h cells in culture

Takenouchi, Takato, Munekata, Eisuke

Journal:

Neuroscience Letters

Year:

1994

Language:

english

File:

PDF, 377 KB

english, 1994

47

Extracellular ATP does not induce P2X7 receptor-dependent responses in cultured renal- and liver-derived swine macrophages

Takenouchi, Takato, Suzuki, Shunichi, Shinkai, Hiroki, Tsukimoto, Mitsutoshi, Sato, Mitsuru, Uenishi, Hirohide, Kitani, Hiroshi

Journal:

Results in Immunology

Year:

2014

Language:

english

File:

PDF, 1.95 MB

english, 2014

48

[IRE 1987 International Electron Devices Meeting - ()] 1987 International Electron Devices Meeting - Process technologies for high density, high speed 16 megabit dynamic RAM

Horiguchi, F., Nitayama, A., Hieda, K., Hamamoto, T., Tsuda, K., Sunouchi, K., Takenouchi, N., Aritome, S., Takato, H., Kimura, M., Yamabe, K., Nakase, M., Kamata, Y., Masuoka, F.

Year:

1987

Language:

english

File:

PDF, 310 KB

english, 1987

49

Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macrophages

Sakuma, Chisato, Sato, Mitsuru, Takenouchi, Takato, Kitani, Hiroshi

Journal:

Molecular Immunology

Year:

2015

Language:

english

File:

PDF, 2.39 MB

english, 2015

50

Disease modifying effect of adiponectin in model of α -synucleinopathies

Sekiyama, Kazunari, Waragai, Masaaki, Akatsu, Hiroyasu, Sugama, Shuei, Takenouchi, Takato, Takamatsu, Yoshiki, Fujita, Masayo, Sekigawa, Akio, Rockenstein, Edward, Inoue, Satoshi, La Spada, Albert R.,

Journal:

Annals of Clinical and Translational Neurology

Year:

2014

Language:

english

File:

PDF, 954 KB

english, 2014